Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes
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چکیده
منابع مشابه
Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes.
Current knowledge regarding acute regulation of adipocyte lipolysis is largely based on receptor-mediated activation or inhibition of pathways that influence intracellular levels of cAMP, thereby affecting protein kinase A (PKA) activity. We recently identified synthetic ligands of α-β-hydrolase domain containing 5 (ABHD5) that directly activate adipose triglyceride lipase (ATGL) by dissociatin...
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Leptin, the ob gene product, is produced by adipose tissue and is submitted to a complex hormonal and metabolic regulation. Leptin plays a critical role in the balance of body weight. Here we report on secretion and hormonal regulation of leptin by brown adipocytes. Using the recently established T37i cell line, we show that leptin expression and secretion occurred as a function of cell differe...
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Background Obesity and associated metabolic disorders result from an imbalance between energy intake and expenditure. White fat is the major site of energy storage in the body. In contrast, brown adipose tissue (BAT), which is highly vascularized and densely packed with mitochondria, is important for energy dissipation by thermogenesis. BAT plays an important role in human neonates in non-shive...
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Both brown adipocytes (BAC) and beige cells hold therapeutic potential for the treatment of metabolic disorders. Unfortunately, the amount and activity of these cells are limited in adults. Although BAC marker expression has been shown in peri-renal adipose tissues in children and adults, functional assessment is lacking. Furthermore, it is entirely unknown whether adipose progenitors are prese...
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ژورنال
عنوان ژورنال: Nature Metabolism
سال: 2019
ISSN: 2522-5812
DOI: 10.1038/s42255-019-0066-3